info@RegenProtocols.com
561-325-7000
141 NW 20th St., Suite G1 Boca Raton, FL 33431

Neuropathic Pain & Nerve Repair Protocol

Summary

A targeted regenerative framework that supports nerve repair and reduces chronic neuropathic pain signaling with neurotrophic peptides and mitochondrial support.

Overview

A targeted regenerative framework for neuropathic pain and peripheral nerve injury. The protocol combines neurotrophic support peptides, mitochondrial stabilizers, immune modulators, and regulators of central sensitization to promote nerve repair while reducing chronic neuropathic pain signaling.

The goal is to interrupt pain chronification, restore neuronal integrity, and improve functional neurological recovery.

Clinical scope

  • Peripheral neuropathy
  • Post-surgical nerve damage
  • Diabetic neuropathy
  • Complex regional pain syndrome (CRPS)
  • Radiculopathy
  • Post-herpetic neuralgia

Core neuro-regenerative stack

AgentRouteDoseFrequencyDuration
BPC-157SubQ500 mcgTwice daily8–12 weeks
ARA-290SubQ2–4 mgThree times weekly8–12 weeks
SS-31SubQ1.0 mgDaily8 weeks
SelankIntranasal400 mcgTwice daily4–8 weeks
KPVSubQ500 mcgDaily6–8 weeks

Phase structure

1

Phase 1: Neuro-inflammatory controlWeeks 1–4

  • BPC-157 twice daily
  • ARA-290 three times weekly
  • SS-31 daily for mitochondrial support
  • KPV daily for inflammatory modulation
  • Selank twice daily to reduce central sensitization
2

Phase 2: Active nerve regenerationWeeks 5–8

  • Maintain BPC-157 and ARA-290
  • Continue SS-31 through Week 8
  • Assess sensory improvement and pain trend
  • Taper Selank if central symptoms stabilize
3

Phase 3: Remodeling and consolidationWeeks 9–12

  • Continue BPC-157 and ARA-290 as indicated
  • Discontinue SS-31 after 8 weeks unless clinically necessary
  • Taper KPV
  • Reassess neurological recovery and pain thresholds

Rationale

ARA-290 is the centerpiece of this protocol. It is an innate repair receptor (IRR) agonist derived from erythropoietin, and it promotes nerve repair and reduces neuropathic pain through non-opioid pathways.

BPC-157 provides neurotrophic support and has shown reparative effects in preclinical nerve injury models. SS-31 stabilizes neuronal mitochondrial membranes and reduces oxidative stress, a key contributor to the chronification of neuropathic pain. Selank modulates GABAergic signaling and reduces central sensitization. KPV supports inflammatory regulation without broad immunosuppression.

Expected outcomes

  • Reduction in neuropathic pain intensity
  • Improved nerve conduction and sensory function
  • Decreased central sensitization
  • Enhanced mitochondrial stability within neurons
  • Reduced risk of pain chronification

Monitoring

  • Neuropathic pain scoring (VAS or neuropathic pain scale)
  • Sensory assessment (light touch, vibration, temperature)
  • Functional neurological evaluation
  • Metabolic markers in diabetic patients
  • Clinical reassessment at Weeks 4, 8, and 12

Contraindications

  • Active malignancy
  • Pregnancy or breastfeeding
  • Uncontrolled systemic infection
  • Severe hepatic or renal impairment
  • Known hypersensitivity to any compound
Clinical disclaimer. This protocol is provided for informational and educational purposes for licensed healthcare professionals. These compounds and strategies are not intended to diagnose, treat, cure, or prevent any disease. The statements have not been evaluated by the Food and Drug Administration. Clinical evaluation and individualized medical judgment are required before implementation.
Facebook
Twitter
Email
Print

Related protocols

TEST Protocol QA 2

TEST – Protocol QA

Neuro-Restorative Cognitive Protocol

A two-phase neuro-restorative approach to age-related cognitive decline and executive dysfunction that pairs peptides with cognitive behavioral therapy.

Related article